Christopher Eccleston is set to appear in a screenplay by A Clockwork Orange author Anthony Burgess which has never been produced before.
The drama, titled Schreber, was written in 1975 for Hollywood heavyweight Burt Lancaster and has been adapted for BBC Radio 3.
The story follows a 19th century German High Court judge, Daniel Schreber, who suffers a series of nervous breakdowns.
Former Doctor Who star Eccleston said: "I'm chuffed to bits to be playing Schreber in Anthony Burgess's unproduced screenplay.
"The role was originally meant to be played by a personal acting hero of mine – Burt Lancaster – and deals with male mental health and challenges traditional gender roles and thinking."
Schreber will be broadcast on March 22.
BBC Radio 3 has announced a string of other dramas featuring actors including Simon Russell Beale, David Suchet and Toby Jones.
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